Benznidazole generic benznidazole is a nitroimidazole antiprotozoal agent prescribed to treat children of 2 to 12 years of age suffering from american trypanosomiasis or. Pdf randomized trial of benznidazole for chronic chagas. National institute of diabetes and digestive and kidney diseases. History and global supply of benznidazole and nifurtimox. History of severe alcohol abuse, or any other drug addiction within past 2 years. New scheme of intermittent benznidazole administration in patients. Reactions have included severe skin and soft tissue reactions. Network mediakit reprints and eprints sponsored supplements branded books. Open ind is a significant step to advancing the benznidazole development programcompany remains on track to submit a new drug application in the first. Benznidazole is an antiparasitic medication used in the treatment of chagas disease. Benznidazole tablets, a nitroimidazole antimicrobial, is indicated in pediatric patients 2 to 12. Food and drug administration 10903 new hampshire avenue silver spring, md 20993 1888infofda 18884636332 contact fda.
Benznidazole ind for chagas disease receives clearance by. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. A pilot study with intermittent doses of benznidazole at 5 mgkgday in two daily doses every 5 days for a total of 60. Commons is a freely licensed media file repository. Pdf severe immune thrombocytopaenia in a patient taking. Randomized trial of benznidazole for chronic chagas. The information contained in the truven health micromedex products as delivered by goodrx is intended as an educational aid only. Benznidazole 100 mg tablets are functionally scored tablets which can be split into onehalf 50 mg or onequarter 25 mg at the scored lines to provide doses less than 100 mg. Compare prices, print coupons and get savings tips for benznidazole and other parasitic infection drugs at cvs, walgreens, and other pharmacies. Clinical evaluation included systematized history, symptom surveillance.
Reimbursement support will be provided for benznidazole tablets including benefit investigations, prior authorization, and appeals assistance. Information from its description page there is shown below. Pdf drugs for neglected tropical diseases ntd are being excessively priced in. Benznidazole tablets 100 mg are functionally scored tablets which can be split into onehalf 50 mg or onequarter 25 mg at the scored lines to provide doses less than 100 mg see instructions for use. Benznidazole tablets are contraindicated in patients with a history of hypersensitivity reactions to benznidazole or other nitroimidazole derivatives. Benznidazole is a nitroimidazole similar to metronidazole and is associated with serum enzyme elevations during therapy in up to 10% of patients but has not linked to cases of clinically apparent acute liver injury. In this doubleblind, placebocontrolled trial involving 2854 patients with chagas cardiomyopathy, no clinical benefit was found with 2 to 3 months of benznidazole therapy during 5. Tolerance of benznidazole in a united states chagas disease clinic. The patient, who had been living in spain for more than 10 years, had a medical history of chronic kidney disease on haemodialysis treatment starting in 2012.
Benznidazole is an orally available, broad spectrum antimicrobial agent used in the treatment of chagas disease. Efficacy and safety of chagas disease drug therapy and treatment. Benznidazole drug information indications, dosage, side. Chagas disease, trypanosomiasis, benznidazole, united states, drug tolerance. Pdf access to benznidazole for chagas disease in the united. The main objectives of this study were to describe the adverse events ae in patients with chronic chagas disease treated with benznidazole, determine the. Highdose benznidazole in a 62yearold bolivian kidney transplant. Benznidazole was administered to 31 patients, and adverse effects were observed in 10 of them. Access to benznidazole for chagas disease in the united states. Benznidazole is an antiprotozoal indicated for the treatment of chagas disease, or american trypanosomiasis, a parasitic infection caused by trypanosoma cruzi. While it is highly effective in early disease this decreases in those who have longterm infection. Randomized trial of benznidazole for chronic chagas cardiomyopathy. Brand name generic name benznidazole nh healthy families.